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Product Name
Rhesus EGFR/HER1/ErbB1 (Fc Tag) recombinant protein
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Description
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
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Protein short names
NISBD2; MENA; WA2; ERRP; ERBB1; PIG61; HER1; ERBB; ERRB1; ERBB-1; RP23-295E4.1; EGFR; WA5; AI552599; 9030024J15RIK; WA-2
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Uniprot ID
A0A0A0MQ66
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus EGFR (XP_001107305.1) (Met1-Ser645) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus EGFR consists 859 amino acids and predicts a molecular mass of 95.4 kDa.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Rhesus EGFR / HER1 / ErbB1 Protein (Fc Tag)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"