-
Product Name
Rhesus DKK-1 (256 Asn/Gln, Fc Tag) recombinant protein
- Documents
-
Description
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.
-
Protein short names
SK; DICKKOPF 1; DKK-1; MDKK-1; S; HDKK 1; DKK1
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the rhesus DKK1 (XP_001098844.1) precursor (Met 1-His 266) (256Asn/Gln) was fused with the Fc region of mouse IgG1 at the C-terminus via a peptide linker.
-
Protein Species
Rhesus
-
Molecular weight
The recombinant rhesus DKK1/mFc chimera is a disulfide-linked homodimmer. The reduced monomer comprises 479 amino acids and has a predicted molecular mass of 53.5 kDa. As a result of glycosylation, the apparent molecular mass of rhesus DKK1/mFc monomer is approximately 60-70 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 90 % as determined by SDS-PAGE
-
Validations
Rhesus DKK-1 / Dkk1 Protein (256 Asn/Gln, Fc Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"