Rhesus CD219 / IL10RA (Fc Tag) recombinant protein

Rhesus CD219 / IL10RA (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD219, also known as IL10RA, is a receptor for interleukin 10. CD219 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It is structurally related to IFN receptors. It has been reported that CD219 promotes survival of progenitor myeloid cells. Activation of CD219 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

ALPHA; IL-10R SUBUNIT 1; AW553859; CD210; IL-10 RECEPTOR SUBUNIT ALPHA; IL-10R SUBUNIT ALPHA; IL10R; CDW210; INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA; INTERLEUKIN-10 RECEPTOR ALPHA CHAIN; MIL-10R; INTERLEUKIN 10 RECEPTOR; IL-10R1; IL-10RA; CDW210A; IL10RA; CD210A; INTERLEUKIN-10 RECEPTOR SUBUNIT 1; HIL-10R

F7AR90

Human Cells

A DNA sequence encoding the rhesus IL10RA (XP_001092736.1) (Thr9-Asn245) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus IL10RA comprises 458 amino acids and has a calculated molecular mass of 51.8 KDa.

> 95 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
Immobilized Rhesus IL10RA-Fc (cat:504750) at 10 μg/ml (100 μl/well) can bind biotinylated human IL10 (Cat:500745), The EC₅₀ of biotinylated human IL10 (Cat:500745) is 39.0-92.0 ng/ml.