Rhesus ADAM8(CD156) (His Tag) recombinant protein

Rhesus ADAM8(CD156) (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ADAM8, also known as CD156, is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM8 is possiblely involved in extravasation of leukocytes As a metalloprotease, ADAM8 also may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma.

CD156A; CELL SURFACE ANTIGEN MS2; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8; A DISINTEGRIN AND METALLOPROTEASE DOMAIN (ADAM) 8; MS2; A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 8; E430039A18RIK; CD156; MACROPHAGE CYSTEINE-RICH GLYCOPROTEIN; A DISINTEGRIN AND METALLOPROTEASE DOMAIN 8; ADAM 8; ADAM8

Human Cells

A DNA sequence encoding the rhesus ADAM8 (XP_002805919.1) (Met1-Pro497) was expressed with a polyhistidine tag at the C-terminus.

Rhesus

The recombinant rhesus ADAM8 comprises 488 amino acids and has a calculated molecular mass of 53.6 KDa.

(50.8+34.6) % as determined by SDS-PAGE

Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2, R&D Systems, Catalog # ES003.
The specific activity is > 0.5 pmols/min/μg.