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Product Name
Rat HER2/ErbB2 (Fc Tag) recombinant protein
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Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
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Protein name
Receptor tyrosine-protein kinase erbB-2
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Protein short names
C-ERBB-2; ERBB2; RP23-355L10.8; C-NEU; HER-2; NEU; CD340; MKIAA3023; NGL; HER2; TKR1; C-ERBB2; HER-2/NEU; ERBB-2; MLN19
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Uniprot ID
P06494
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Gene Name
Erbb2; Neu
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat ErbB2 (AAH61863.1) extracellular domain (Met 4-Thr 656) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat ErbB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 872 amino acids and predicts a molecular mass of 97 kDa. The apparent molecular mass of the rat ErbB2/Fc monomer is approximately 130 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Rat HER2 / ErbB2 Protein (Fc Tag) SDS-PAGE
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