Human DEP1 / PTPRJ (aa 997-1337, His Tag) recombinant protein

Human DEP1 / PTPRJ (aa 997-1337, His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Receptor-type tyrosine-protein phosphatase eta

DENSITY ENHANCED PHOSPHATASE-1; SCC-1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ETA; PROTEIN-TYROSINE PHOSPHATASE RECEPTOR TYPE J; DEP-1; R-PTP-J; PROTEIN-TYROSINE PHOSPHATASE ETA; DENSITY-ENHANCED PHOSPHATASE 1; CD148 ANTIGEN; RECEPTOR TYPE; PTPBETA2; R-PTP-ETA; J POLYPEPTIDE; HUMAN DENSITY ENHANCED PHOSPHATASE-1; BET; HPTP ETA; RPTPJ; BYP; PTPB2; AI450271; PROTEIN TYROSINE PHOSPHATASE; CD148; RCG_26744; HPTPETA; DEP1; SCC1

Q12913

PTPRJ; DEP1

E. coli

A DNA sequence encoding the human PTPRJ (Q12913) cytoplasmic domain (Arg 997-Ala 1337) was expressed, with a polyhistide tag at the N-terminus.

Human

The recombinant human PTPRJ (aa 997-1337) consists of 352 amino acids and has a calculated molecular mass of 41KDa. It migrates as an approximately 37 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE