Cynomolgus Tie2?CD202b?/TEK (Fc Tag) recombinant protein

Cynomolgus Tie2?CD202b?/TEK (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

Receptor protein-tyrosine kinase

VMCM1; HYK; CD202B; TIE2; TIE-2; AA517024; VMCM; RP23-345A23.1; TEK; STK1

G7PS68

EGM_06937

Human Cells

A DNA sequence encoding the cynomolgus TEK (G7PS68) (Met1-Lys745) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus TEK is a disulfide-linked homodimer. The reduced monomer comprises 964 amino acids and has a calculated molecular mass of 107.6 KDa.The apparent molecular mass of the protein is approximately 63 KDa respectively in SDS-PAGE.

> 95 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
Immobilized mouse S1h-3C-mANGPT2 (Cat:501251) at 10 μg/ml (100 μl/well) can bind Cynomolgus TEK-Fc, The EC₅₀ of Cynomolgus TEK-Fc is 0.7-1.64 μg/ml.