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Product Name
Rat Junctional Adhesion Molecule A (Fc Tag) recombinant protein
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Description
Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.
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Protein short names
F11R; JAM-A; KAT; LY106; CD321; ESTM33; JAM-1; JCAM; JAM; JAM1; JCAM1; AA638916; PAM-1; 9130004G24; JAMA
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat F11R () was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat F11R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 453 amino acids and has a predicted molecular mass of 49.9 kDa. The apparent molecular mass of the protein is approximately 60 kDa in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Rat JAM-A / F11R Protein (Fc Tag) SDS-PAGE
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