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Product Name
Rat IL23R / IL23 Receptor (His Tag) recombinant protein
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Description
IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.
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Protein short names
IL-23R; INTERLEUKIN-23 RECEPTOR; IL-23 RECEPTOR
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Uniprot ID
F1LX96
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat IL23R (XP_003753958.1) (Met1-Asp367) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat IL23R consists 378 amino acids and predicts a molecular mass of 43.8 kDa.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Rat IL23R / IL23 Receptor Protein (His Tag)
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