Rat IL18R1 (Fc Tag) recombinant protein

Rat IL18R1 (Fc Tag) recombinant protein

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Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

Interleukin 18 receptor 1 (Predicted), isoform CRA_a

CD218A; IL18RA; IL18R1; IL18RALPHA; IL1RRP; CDW218A; IL-1RRP

D3ZRM2

Il18r1; Il18r1_predicted; rCG_22159

Human Cells

A DNA sequence encoding the rat IL18R1 (NP_001100375.1) extracellular domain (Met 1-Gly 326) was fused with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat IL18R1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 550 amino acids and predicts a molecular mass of 62.5kDa. The apparent molecular mass of the rat IL18R1/Fc monomer is approximately 105 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 97 % as determined by SDS-PAGE