Rat ICOS Ligand/B7-H2 (His Tag) recombinant protein

Rat ICOS Ligand/B7-H2 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

B7RP-1; LY115L; GI50; ICOSL; B7H; ICOSLG; GL50-B; LICOS; BG071784; MKIAA0653; KIAA0653; B7H2; GL50; B7RP1; ICOS-L; B7-H2; CD275; AU044799; ICOS LIGAND

F1LVL2

Human Cells

A DNA sequence encoding the rat ICOSLG (XP_006223893.1) (Met1-Lys261) was expressed with a polyhistidine tag at the C-terminus.

Rat

The recombinant rat ICOSLG consists 250 amino acids and predicts a molecular mass of 28.6 kDa.

> 95 % as determined by SDS-PAGE