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Product Name
Rat Erbb2/Neu (His tag) recombinant protein
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Description
ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.
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Protein name
erb-b2 receptor tyrosine kinase 2(Erbb2)
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Protein short names
Neu
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Uniprot ID
P06494
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Rat Erbb2/Neu Ala67-Val323 is expressed with a 6His tag at the C-terminus.
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Protein Species
Rat
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Purity
>95% as determined by SDS-PAGE.
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Validations
Rat Erbb2/Neu (His tag) recombinant protein
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