Rat CD40/TNFRSF5 (His Tag) recombinant protein
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
Protein short names
CDW40; AI326936; IMD3; P50; IGM; T-BAM; BP50; TNFRSF5; CD40; HIGM1; MGC9013; GP39; TRAP; RP23-428M13.1
A DNA sequence encoding the rat CD40 (Met1-Arg193) was expressed, fused with a polyhistidine tag at the C-terminus.
The recombinant rat CD40 comprises 185 amino acids and predicts a molecular mass of 20.6 kDa. The apparent molecular mass of the recombinant protein is approximately 28 kDa in SDS-PAGE under reducing conditions due to glycosylation.
> 95 % as determined by SDS-PAGE
Rat CD40 / TNFRSF5 Protein (His Tag) SDS-PAGE
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