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Product Name
Rat CD302/CLEC13A (His Tag) recombinant protein
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Description
CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. DCL-1 ectodomain contains only one CRD, whereas other type I transmembrane C-type lectins contain more than one domain (e.g. selectins and MMR). DCL-1 CP contains several putative motifs, including a Tyr-based internalization, a cluster of acidic amino acids, and Ser and Tyr phosphorylation motifs, suggesting that DCL-1 CP mediates not only endocytosis and late endosome targeting but also signaling. DCL-1 may be another cell/matrix adhesion receptor integrated in cell adhesion complexes and that DCL-1 dysfunction may affect APC adhesion and migration, causing suppression of APC function.
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat CD302 (Met1-His165) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat CD302 comprises 156 amino acids and predicts a molecular mass of 18.1 kDa. The apparent molecular mass of the recombinant protein is approximately 18 and 22 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
(49.5+41.9) % as determined by SDS-PAGE
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Validations
Rat CD302 / CLEC13A Protein (His Tag) SDS-PAGE
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