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Product Name
Rat CD297 (His Tag) recombinant protein
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Description
ADP-ribosyltransferase 4 (Dombrock blood group), also known as Mono-ADP-ribosyltransferase 4(ART4), Dombrock blood group carrier molecule and CD297, is a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. ART4 could be detected on HEL cells and erythrocytes by FACS analysis while it was absent from activated monocytes, despite the presence of ART4 mRNA in these cells. ART is also known as the carrier of the Dombrock blood group alloantigens (Do) which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.
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Protein short names
4432404K01RIK; MONO(ADP-RIBOSYL)TRANSFERASE; ADP-RIBOSYLTRANSFERASE 4 (DO BLOOD GROUP); DOMBROCK BLOOD GROUP CARRIER MOLECULE; MONO(ADP-RIBOSYL)TRANSFERASE 4; NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 4; ECTO-ADP-RIBOSYLTRANSFERASE 4; MONO-ADP-RIBOSYLTRANSFERASE 4; ARTC4; CD297; DO; DOK1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat ART4 (Met1-Lys269) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat ART4 comprises 251 amino acids and predicts a molecular mass of 28.4 kDa. The apparent molecular mass of the recombinant protein is approximately 36-41 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Rat ART4 Protein (His Tag) SDS-PAGE
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