Rat CD157/BST1 (Fc Tag) recombinant protein

Rat CD157/BST1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD157, also known as ADP-ribosyl cyclase 2, is an ectoenzyme sharing several characteristics with ADP-ribosyl cyclase CD38. CD157 was originally identified as a bone marrow stromal cell molecule (BST-1) with a glycosylphosphatidylinositol (GPI) anchor to bind to the cell surface. CD157 is prevalently expressed by cells of the myeloid lineage. CD157 could act as a receptor with signal transduction capability. Further, it regulates calcium homeostasis and promotes polarization in neutrophils and mediates superoxide (O₂₋) production in the human U937 myeloid line.

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

CD157; 114/A10; LY65; A530073F09; BST1; BSTA1; BP3; BP-3

Q63072

Bst1

Human Cells

A DNA sequence encoding the rat BST1 (Q63072) (Met1-Glu293) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat BST1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 506 amino acids and has a predicted molecular mass of 56.8 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE