Rat Ccl5/Scya5 (His tag) recombinant protein

Cat.#: 518849

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Product Information

  • Product Name
    Rat Ccl5/Scya5 (His tag) recombinant protein
  • Documents
  • Description
    C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leukocyte adhesion and activation as well as CCL5’s interaction with the chemokine CXCL4/PF4.The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes.CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature.
  • Protein name
    C-C motif chemokine ligand 5(Ccl5)
  • Protein short names
    Scya5
  • Uniprot ID
    P50231
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Rat Ccl5/Scya5 Ser25-Ser92 is expressed with a 6His tag at the N-terminus.
  • Protein Species
    Rat
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Rat Ccl5/Scya5 (His tag) recombinant protein

    Rat Ccl5/Scya5 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"