Rat RAB7A / Rab-7a (His Tag) recombinant protein

Rat RAB7A / Rab-7a (His Tag) recombinant protein

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Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.

Ras-related protein Rab-7a

RAB7; PRO2706

P09527

Rab7a; Rab7

E. coli

A DNA sequence encoding the rat Rab7a (NP_076440.1) (Met1-Cys207) was expressed with a polyhistidine tag at the N-terminus.

Rat

The recombinant rat Rab7a consists 225 amino acids and predicts a molecular mass of 25.7 kDa.

> 90 % as determined by SDS-PAGE.