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Product Name
Human RAB31/RAB22B (His Tag) recombinant protein
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Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
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Protein name
Ras-related protein Rab-31
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Protein short names
AI415285; 1700093E07RIK ; RAB22B; 1700093E07RIK
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Uniprot ID
Q13636
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Gene Name
RAB31; RAB22B
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RAB31 (NP_006859.2) (Met1-Cys195) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human RAB31 consists of 213 amino acids and predicts a molecular mass of 23.9 kDa. It migrates as an approximately 26 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human RAB31 / Rab22B Protein (His Tag) SDS-PAGE
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