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Product Name
Human RAB11B (His Tag) recombinant protein
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Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
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Protein name
Ras-related protein Rab-11B
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Protein short names
H-YPT3; A730055L17RIK
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Uniprot ID
Q15907
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Gene Name
RAB11B; YPT3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human RAB11B (ABQ59034.1) (Gly2-Cys215) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human RAB11B consists 233 amino acids and predicts a molecular mass of 26.3 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human RAB11B Protein (His Tag)
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