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  • Ranacyclin-B-LK2 peptide

Ranacyclin-B-LK2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 300262

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* Buy 1 get 1 free (?) What is TFA?

Special Price 350.40 USD

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Product Information

  • Product Name
    Ranacyclin-B-LK2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-SALVGCWTKSWPPKPCFGR-OH
  • Sequence
    H-Ser-Ala-Leu-Val-Gly-Cys-Trp-Thr-Lys-Ser-Trp-Pro-Pro-Lys-Pro-Cys-Phe-Gly-Arg-OH (disulfide bond: Cys6-Cys16)
  • Length (aa)
    19
  • Peptide Purity (HPLC)
    95.85%
  • Molecular Formula
    C98H144N26O23S2
  • Molecular Weight
    2118.52
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Ranacyclin-B-LK2 is a small serine protease inhibitor peptide identified from the skin secretion of the Ranidae frog species Limnonectes kuhlii. It belongs to the Ranacyclin-B peptide family, which is characterized by a conserved GCWTKSXXPKPC motif in the primary structure. The peptide is composed of 19–20 amino acid residues and is cationic, containing multiple basic residues (arginine and/or lysine) with no acidic amino acids. Ranacyclin-B-LK2 exhibits both trypsin-inhibitory and antimicrobial activities, functioning as a bi-functional defensive molecule in amphibian skin. The peptide adopts a conformation stabilized by a disulfide bond between cysteine residues at positions P4 and P7′, forming an 11-residue reactive loop (CWTKSPPKPC) that differs from the typical 9-residue loop found in other Bowman–Birk inhibitors. The trypsin-inhibitory constant (Ki) for Ranacyclin-B-LK2 is in the order of 10−6 M, and it demonstrates antimicrobial activity against Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 11.8 μM.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Yan X, Liu H, Yang X, et al. Bi-functional peptides with both trypsin-inhibitory and antimicrobial activities are frequent defensive molecules in Ranidae amphibian skins. Amino Acids. 2012;43(1):309-16.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"