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Product Name
Human LAMTOR2/ROBLD3/MAPBPIP (His Tag) recombinant protein
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Description
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
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Protein name
Ragulator complex protein LAMTOR2
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Protein short names
RAGULATOR2; MAPKSP1AP; 2010111E04RIK; RP11-336K24.9; LAMTOR2; ROBLD3; HSPC003; AL022628; ENDAP; MAPBPIP; RAB25; P14
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Uniprot ID
Q9Y2Q5
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Gene Name
LAMTOR2; MAPBPIP; ROBLD3; HSPC003
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human LAMTOR2 isoform 1 (Q9Y2Q5-1) (Met 1-Ser 125) was expressed, with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human LAMTOR2 consisting of 136 amino acids and has a calculated molecular mass of 15 kDa. The apparent molecular mass of the protein is approximately 13 kDa in SDS-PAGE under reducing conditions
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human LAMTOR2 / ROBLD3 / MAPBPIP Protein (His Tag) SDS-PAGE
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