Rabbit NGFR/P75 (His Tag) recombinant protein

Rabbit NGFR/P75 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. High-affinity nerve growth factor receptor is also referred as Trk familywhose members are bound by some neurotrophins with high affinity. Nerve growth factor binds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to the cell body. The Low-affinity nerve growth factor receptor also named p75 which binds with all kinds of neurotrophins with low affinity. All the four kinds of neurotrophins, including Nerve growth factor, Brain derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 bind to the p75. Studies have proved that NGFR acts as a molecular signal swith that determines cell death or survival by three steps. First, pro-nerve growth factor (prNGF) triggers cell apoptosis by its high affinity binding to p75NTR, while NGF induces neuronal survival with low-affinity binding. Second, p75NTR mediates cell death by combining with co-receptor sortilin, whereas it promotes neuronal survival through combination with proNGF. Third, release of the intracellular domain chopper or cleavage short p75 NTR can independently initiate neuronal apoptosis.

CD271; P75; GP80-LNGFR; TNFRSF16; P75NTR; P75(NTR); LNGFR; P75NGFR; RP23-67E18.6

Human Cells

A DNA sequence encoding the rabbit NGFR (XP_008269543.1) (Met1-Asp242) was expressed with a polyhistidine tag at the C-terminus.

Rabbit

The recombinant rabbit NGFR consists of 232 amino acids and predicts a molecular mass of 24.8 kDa.

> 95 % as determined by SDS-PAGE.