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Product Name
RAB2 antibody
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Description
RAB2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, HEK-293 cells, HeLa cells, mouse lung tissue, rat brain tissue. Positive IHC detected in human brain tissue, human breast cancer tissue. Observed molecular weight by Western-blot: 24 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
RAB2 antibody; RAB2A antibody; Ras related protein Rab 2A antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RAB2 recombinant protein (Accession Number: NM_002865). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human brain using Catalog No:114418(RAB2A antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human brain using Catalog No:114418(RAB2A antibody) at dilution of 1:100 (under 40x lens)
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114418(RAB2A antibody) at dilution of 1:1000
rat brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114418(RAB2A Antibody) at dilution of 1:1000
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Background
The protein belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. This antibody can recognize both RAB2A and RAB2B.
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References
- Luo ML, Gong C, Chen CH. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell reports. 11(1):111-24. 2015.
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