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Product Name
QDPR antibody
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Description
QDPR Rabbit Polyclonal antibody. Positive IHC detected in human ovary tumor tissue. Positive IP detected in mouse liver tissue. Positive WB detected in mouse liver tissue, human liver tissue. Observed molecular weight by Western-blot: 28-30 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DHPR antibody; Dihydropteridine reductase antibody; FLJ42391 antibody; HDHPR antibody; PKU2 antibody; QDPR antibody; SDR33C1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of QDPR recombinant protein (Accession Number: NM_000320). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:114366(QDPR antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:114366(QDPR antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:114366(QDPR antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-QDPR (IP:Catalog No:114366, 4ug; Detection:Catalog No:114366 1:1000) with mouse liver tissue lysate 4000ug.
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Background
Dihydropteridine reductase (QDPR), also named as DHPR and HDHPR, is an essential enzyme in the hydroxylating system of the aromatic amino acids, since it catalyses the regeneration of tetrahydrobiopterin (BH4), the natural cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, from the quininoid-dihydrobiopterin produced in these coupled reactions(PMID:8326489). The QDPR protein is active as a dimer, with a subunit Mr of 26 kDa(PMID:7627180). This protein belongs to the short-chain dehydrogenases/reductases (SDR) family. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C)(PMID:11153907).
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