Q14 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319033
Special Price 152.9 USD
-
Product Name
Q14 peptide
- Documents
-
Sequence Shortening
H-GIYVIWGPITERKKRRKG-NH2
-
Sequence
H-Gly-Ile-Tyr-Val-Ile-Trp-Gly-Pro-Ile-Thr-Glu-Arg-Lys-Lys-Arg-Arg-Lys-Gly-NH2
-
Length (aa)
18
-
Peptide Purity (HPLC)
95.6%
-
Molecular Formula
C99H166N32O22
-
Molecular Weight
2156.57
-
Source
Synthetic
-
Form
Powder
-
Description
Q14 is a peptide derived from the transmembrane domain of the mitochondrial anchored deubiquitinating enzyme USP30 (ubiquitin specific peptidase 30). Q14 can easily cross the cell membrane, bind to mitochondrial anchored USP30 directly, degrade outer mitochondrial membrane (OMM) proteins, promote mitochondrial fission, and trigger mitophagy. Q14 increases mitophagy through two distinct mechanisms, autoinhibition of USP30, and accelerated autophagosome formation through the LC3-interacting region (LIR) of Q14, synergistically enhancing mitophagy. USP30 antagonises PRKN/parkin-mediated mitophagy, making it a potential target for treating Parkinsons disease.
-
Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
-
References
- Qin X (2022) Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30. Autophagy 1-20 PMID: 34989313
-
About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
-
Molar Concentration Calculator
-
Dilution Calculator
-
Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"