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Human PDK-1 (His Tag) recombinant protein

Cat.#: 502126

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Product Information

  • Product Name
    Human PDK-1 (His Tag) recombinant protein
  • Documents
  • Description
    Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
  • Protein name
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
  • Protein short names
    PDK1; OTTHUMP00000205082; B830012B01; PDK-1; D530020C15RIK; RP23-5K9.5; OTTHUMP00000205076
  • Uniprot ID
    Q15118
  • Gene Name
    PDK1; PDHK1
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of human PDK1 (NP_002601.1) (Ser 29-Ala 436) was expressed, with a polyhistidine tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human PDK1 consists of 427 amino acids and has a calculated molecular mass of 48.6 kDa. It migrates as an approximately 45 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    No Kinase Activity
  • Validations

    Human PDK-1 Protein (His Tag) SDS-PAGE

    Human PDK-1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"