Px-Moricin peptide

Px-Moricin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

1 Vial

H-APKVNVNALKKGGRVIKKGLGVIGAAGTAHEVYNHVRNRNQG-Amidation

H-Ala-Pro-Lys-Val-Asn-Val-Asn-Ala-Leu-Lys-Lys-Gly-Gly-Arg-Val-Ile-Lys-Lys-Gly-Leu-Gly-Val-Ile-Gly-Ala-Ala-Gly-Thr-Ala-His-Glu-Val-Tyr-Asn-His-Val-Arg-Asn-Arg-Asn-Gln-Gly-Amidation

42

95.2%

C₁₉₁H₃₂₅N₆₇O₅₂

4392.02

Synthetic

Px-Moricin is a novel AMP moricin from diamondback moth (Plutella xylostella). Px-Mor exhibited a broad antimicrobial spectrum against Gram positive bacteria (GPB), Gram negative bacteria (GNB) and fungi. Moreover, scanning electron microscopy and transmission electron microscopy (TEM) revealed that Px-Mor can cause obvious morphological alterations in A. pullulans, which demonstrated its powerful effect on the mycelia growth inhibition. The relative expression levels of Px-Mor were highest in fourth instar and prepupa stage, suggesting that moricin played different roles at different developmental stages. Px-Mor may be mainly expressed in changeable period of metamorphosis of prepupa development, which illustrated that Moricin have certain biological significance during the process of metamorphosis.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Xu X, Zhong A, Wang Y, et al. Molecular Identification of a Moricin Family Antimicrobial Peptide (Px-Mor) From Plutella xylostella With Activities Against the Opportunistic Human Pathogen Aureobasidium pullulans. Front Microbiol. 2019

Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

TFA Removal Service is recommended for:

• Peptides that will be used in cellular assays
• Peptides that will be used as APIs or in manufactured products
• For hydrophilic peptides containing numerous basic residues