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Product Name
Mouse IL11RA/IL-11RA (His Tag) recombinant protein
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Description
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.
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Protein name
Putative uncharacterized protein
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Protein short names
AI314697; MGC2146; IL11RA; IL-11RA; NR1; GP130; IL11RA2; RP23-167I12.2; IL11RA1; HCG_2011440
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Uniprot ID
Q64385
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Gene Name
Il11ra1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse IL11R? (NP_001156873.1) (Met 1-Gln 367) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse IL11R? consists of 355 amino acids and has a calculated molecular mass of 39.2 kDa. As a result of glycosylation, the apparent molecular mass of rmIL11R? is approximately 45-50 kDa in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind mouse IL6ST in a functional ELISA.
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Validations
Mouse IL11RA / IL11R? Protein (His Tag) SDS-PAGE
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