Cynomolgus TIM-3/HAVCR2 (Fc Tag) recombinant protein

Cynomolgus TIM-3/HAVCR2 (Fc Tag) recombinant protein

• DataSheet
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Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.

Putative uncharacterized protein

KIM-3; MGC124150; FLJ14428; HAVCR2; HAVCR-2; RP23-248K2.7; TIMD-3; MGC124149; TIM-3; TIM3; TIMD3

G7P6Q7

EGM_15593

Human Cells

A DNA sequence encoding the cynomolgus TIM3 (EHH54703.1) (Met1-Arg201) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus TIM3 comprises 418 amino acids and has a calculated molecular mass of 46.4 KDa. The apparent molecular mass of the protein is approximately 60.5 and 35.8 KDa in SDS-PAGE.

(70.9+26.4) % as determined by SDS-PAGE