SVDPIDGDLIG peptide

SVDPIDGDLIG peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

H-SVDPIDGDLIG-NH2

H-Ser-Val-Asp-Pro-Ile-Asp-Gly-Asp-Leu-Ile-Gly-NH2

11

95.37%

C₄₇H₇₈N₁₂O₁₈

1099.18

Synthetic

Powder

SVDPIDGDLIG is a peptide potentially yielded from a precursor protein in red flour beetle (Tribolium castaneum).
The precursor protein Glean 05944 potentially yields multiple copies of SVDPIDGDLIG, along with other peptides, and appears to be a unique protein to Tribolium castaneum.
The SVDPIDGDLIG-containing Glean 05944 is a prohormone which has little similarity to other insect prohormones.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Amare A, Sweedler JV. Neuropeptide precursors in Tribolium castaneum. Peptides. 2007;28(6):1282-91.

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.