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  • PTP Peptide

PTP Peptide

Not For Human Use, Lab Use Only.

Cat.#: 319841

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* Buy 1 get 1 free (?) What is TFA?

Special Price 162.70 USD

Availability: 5 working days
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Product Information

  • Product Name
    PTP Peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-KTLLPTP-OH
  • Sequence
    H-Lys-Thr-Leu-Leu-Pro-Thr-Pro-OH
  • Length (aa)
    7
  • Peptide Purity (HPLC)
    95.5%
  • Molecular Formula
    C36H64N8O10
  • Molecular Weight
    768.93
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The PTP peptide, with the amino acid sequence KTLLPTP, is a plectin-targeted polypeptide. It is designed to specifically bind to plectin-1, a cytoskeletal protein that exhibits aberrant mislocalization on the surface of pancreatic ductal adenocarcinoma (PDAC) cells. This exclusive surface overexpression in neoplastic epithelium makes plectin-1 a target for molecular recognition.

    In the context of a bispecific molecular probe, the PTP peptide is often conjugated with an integrin-targeting RGD peptide. This combination leverages the close biological relationship between plectin and integrins, such as ITGB4, in PDAC. The dual-targeting approach aims to enhance binding affinity and specificity through a synergistic, multi-level interaction with cellular markers overexpressed in distinct tumor compartments.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Wang Q, Yan H, Jin Y, Wang Z, Huang W, Qiu J, Kang F, Wang K, Zhao X, Tian J. A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer. Biomaterials. 2018 Nov;183:173-184. doi: 10.1016/j.biomaterials.2018.08.048. Epub 2018 Aug 26. PMID: 30172243.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"