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Product Name
Human PPM1G (aa 317-546, His Tag) recombinant protein
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Description
Protein phosphatase 1G, also known as Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, Protein phosphatase magnesium-dependent 1 gamma, PP2C-gamma, PPM1G and PPM1C, is a cytoplasm protein which belongs to the PP2C family. PPM1G / PP2C-gamma is widely expressed. It is most abundant in testis, skeletal muscle, and heart. Alternatively spliced transcript variants encoding the same protein have been described. PP2C family members are known to be negative regulators of cell stress response pathways. PPM1G / PP2C-gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. PPM1G / PP2C-gamma also plays a role in regulating cell cycle progression.
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Protein name
Protein phosphatase 1G
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Protein short names
FIN13; AI385652; PPM1G; PPP2CG; MGC2870; PP2CGAMMA; MGC1675; PP2CG
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Uniprot ID
O15355
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Gene Name
PPM1G; PPM1C
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PPM1G (O15355) C-terminal fragment (Met 317-Asp 546) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PPM1G comprises 241 amino acids and has a predicted molecular mass of 26.6 kDa. It migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human PPM1G / PP2C-gamma Protein (aa 317-546, His Tag) SDS-PAGE
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