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Product Name
Human jumping translocation breakpoint / JTB (Fc Tag) recombinant protein
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Description
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
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Protein name
Protein JTB
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Protein short names
PAR; JTB; HJT; JUMPING TRANSLOCATION BREAKPOINT PROTEIN; JUMPING TRANSLOCATION BREAKPOINT; PROSTATE ANDROGEN-REGULATED PROTEIN; RP11-422P24.4; HSPC222; PROTEIN JTB; HJTB; GM622
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Uniprot ID
O76095
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Gene Name
JTB; HSPC222
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human JTB (O76095-1) (Met1-Leu105) was fused with Fc region of mouse IgG at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human JTB/mFc is a disulfide-linked homodimer. The reduced monomer comprises 309 amino acids and has a predicted molecular mass of 34.7 kDa. The apparent molecular mass of the protein is approximately 38 in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human Jumping Translocation Breakpoint / JTB Protein (Fc Tag) SDS-PAGE
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