-
Product Name
Rat COL4A3 (Fc Tag) recombinant protein
- Documents
-
Description
COL4A3 is a major structural component of basement membranes. It is composed of 3 alpha subunits, which are encoded by 6 different genes, alpha 1 through alpha 6. Each of these alpha subunits can form a triple helix structure with 2 other subunits to form COL4A3. Autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli can cause goodpasture syndrome. COL4A3 is also linked to an autosomal recessive form of alport syndrome. COL4A3 is organized in a head-to-head conformation and each gene pair shares a common promoter.
-
Protein name
Protein Col4a3
-
Protein short names
PROCOLLAGEN; ALPHA3(IV); COLLAGEN TYPE IV ALPHA3 CHAIN; TUMSTATIN; ALPHA 3 (GOODPASTURE ANTIGEN); ALPHA-3 POLYPEPTIDE; COLLAGEN IV; ALPHA 3; TYPE IV; COLLAGEN ALPHA-3(IV) CHAIN; COL4A3; COLLAGEN; [A]3(IV)
-
Uniprot ID
F1LRJ1
-
Gene Name
Col4a3; LOC100911572
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the rat COL4A3 (NP_001129231) (Gly1426-His1670) was expressed with Fc region of human IgG1 at the N-terminus.
-
Protein Species
Rat
-
Molecular weight
The recombinant rat COL4A3 comprises 505 amino acids and predicts a molecular mass of 55.2 kDa. The apparent molecular mass of the recombinant protein is approximately 59 kDa in SDS-PAGE under reducing conditions due to glycosylation.
-
Purity
> 85 % as determined by SDS-PAGE
-
Validations
Rat COL4A3 Protein (Fc Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"