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Product Name
Human AGO1 / Argonaute 1 (His Tag) recombinant protein
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Description
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
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Protein name
Protein argonaute-1
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Protein short names
HAGO1; GERP95; EIF2C 1; EIF-2C 1; AGO1; ARGONAUTE 1; EIF2C1; Q99; EIF2C; DKFZP686M13167; ARGONAUTE1
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Uniprot ID
Q9UL18
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Gene Name
AGO1; EIF2C1
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the full length of human AGO1 (NP_036331.1) (Met 1-Ala 857) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human AGO1 consists of 875 amino acids and predicts a molecular mass of 99.5 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human AGO1 / Argonaute 1 / EIF2C1 Protein (His Tag) SDS-PAGE
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