Recombinant PP2AB protein (His tag)

• DataSheet
• COA (Batch NP456436)
• COA (Batch NP456422)
• Material Safety Data Sheets (MSDS)

Recombinant Human Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta), encompassing amino acids 1-309, is a high-purity fragment designed for structural and biochemical studies. This stable, soluble unit retains key functional regions, enabling researchers to investigate the catalytic mechanisms and regulatory roles of this essential phosphatase in cellular signaling pathways.

PP2A-beta, encoded by the PPP2CB gene, serves as the catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase critical for regulating diverse enzymes, signal transduction pathways, and cellular events. It modulates the activity of kinases such as phosphorylase B kinase, casein kinase 2, and MAP-2 kinase, and is integral to striatin-interacting phosphatase and kinase (STRIPAK) complexes. These complexes govern multiple signaling pathways, including Hippo and MAPK, and influence processes like cell growth, differentiation, and immune regulation. Subcellularly, PP2A-beta localizes to the cytoplasm, nucleus, centromeres, and spindle poles, with dynamic presence during mitosis, underscoring its role in cell division and structural organization.

MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG QFHDLMELFR IGGKSPDTNY
LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD
GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV TRRTPDYFLL EHHHHHH