-
Product Name
Mouse PIGR (His Tag) recombinant protein
- Documents
-
Description
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).
-
Protein name
Polymeric immunoglobulin receptor
-
Protein short names
OTTMUSP00000025847; PHOSPHATIDYLINOSITOL GLYCAN; FLJ22667; PIGR; CLASS R; MGC125361; MGC125362
-
Uniprot ID
O70570
-
Gene Name
Pigr
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Lys 645) of mouse PIGR (NP_035212.2) precursor was expressed with a C-terminal polyhistidine tag.
-
Protein Species
Mouse
-
Molecular weight
The secreted recombinant mouse PIGR consists of 638 amino acids and has a calculated molecular mass of 70.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 90-100 kDa protein in SDS-PAGE under reducing conditions.
-
Purity
> 97 % as determined by SDS-PAGE
-
Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PIGR at 5 μg/ml (100 μl/well) can bind mouse IgM with a linear range of 0.156-10 μg/ml.
-
Validations
Mouse PIGR Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"