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Product Name
Human PARP3 (His & GST Tag) recombinant protein
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Description
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
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Protein name
Poly [ADP-ribose] polymerase 3
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Protein short names
A930002C11RIK; ADPRTL3; ADPRTL2; ARTD3; IRT1; PARP-3; ADPRT3; AW990611; PARP3; PADPRT-3
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Uniprot ID
Q9Y6F1
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Gene Name
PARP3; ADPRT3; ADPRTL3
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the C-terminal segment of human PARP3 isoform 1 (Q9Y6F1-1) (Met 1-Leu 533) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PARP3/GST chimera consists of 768 amino acids and has a calculated molecular mass of 87.8 kDa. It migrates as an approximately 95 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human PARP-3 / PARP3 Protein (His & GST Tag) SDS-PAGE
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