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Product Name
Recombinant PODXL protein (His tag)
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Description
Recombinant Human Podocalyxin Fragment (aa 341-461) is a highly stable and soluble protein segment designed for structural and biochemical studies. This fragment, derived from the full-length Podocalyxin protein involved in cell adhesion, morphology regulation, and cancer progression, offers an optimal tool for investigating key molecular mechanisms in cellular dynamics and disease research.
Podocalyxin, encoded by the PODXL gene, plays a dual role in regulating cell adhesion and morphology, contributing to processes such as maintaining filtration pathways in podocytes and enhancing cell migration and invasion in cancer. It localizes to apical cell membranes, microvilli, lamellipodia, and membrane rafts, where it interacts with actin-binding proteins like EZR to influence MAPK and PI3K signaling pathways. This protein is critical in epithelial polarization, lumen formation during renal tubulogenesis, and cancer aggressiveness, making it a significant target for studies in cell biology and oncology.
- Protein name
Podocalyxin- Uniprot ID
O00592- Gene Name
PODXL; PCLP; PCLP1- Source/Expression Host
E. coli- Expression Plasmid/cDNA
DNA encoding 341-461 aa (O00592) were fused with C-terminal 6His tag.- Sequence
MSKIKWAKCE DLETQTQSEK QLVLNLTGNT LCAGGASDEK LISLICRAVK ATFNPAQDKC GIRLASVPGS QTVVVKEITI HTKLPAKDVY ERLKDKWDEL KEAGVSDMKL GDQGPPEEAE DRFSMPLEHH HHHH
- Protein Species
Human- Molecular weight
Predictes a molecular mass of 14.91 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 16 kDa band.- Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.- Activity
Not tested.- Validations
Recombinant PODXL protein (His tag) SDS-PAGE
M: Marker; Lane 1: PODXL; Lane 2: BSA
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
- Protein name