Human PLTP (His Tag) recombinant protein

Human PLTP (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.

Phospholipid transfer protein

PLTP; OD107; RP23-61O3.5; LIPID TRANSFER PROTEIN II; HDLCQ9

P55058

PLTP

Human Cells

A DNA sequence encoding the human PLTP isoform 1 (P55058-1) (Met 1-Val 493) was expressed, fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human PLTP consists of 487 amino acids after removal of the signal peptide and has a predicted molecular mass of 54.5 kDa. As a result of glycosylation, the apparent molecular masss of rh PLTP is approximately 70-80 kDa in SDS-PAGE under reducing conditions.

> 80 % as determined by SDS-PAGE