-
Product Name
Human ETHE1 / HSCO (His Tag) recombinant protein
- Documents
-
Description
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).
-
Protein name
Persulfide dioxygenase ETHE1, mitochondrial
-
Protein short names
PROTEIN ETHE1; ETHYLMALONIC ENCEPHALOPATHY PROTEIN 1 HOMOLOG; ETHYLMALONIC ENCEPHALOPATHY 1; ETHE1; 0610025L15RIK; MITOCHONDRIAL; ETHYLMALONIC ENCEPHALOPATHY PROTEIN 1; MITOCHONDRIAL; YF13H12; HEPATOMA SUBTRACTED CLONE ONE PROTEIN; HSCO
-
Uniprot ID
O95571
-
Gene Name
ETHE1; HSCO
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the human ETHE1 (O95571) (Leu13-Ala254) was expressed with a polyhistidine tag at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human ETHE1 consists of 257 amino acids and predicts a molecular mass of 28.3 KDa. It migrates as an approximately 28 KDa band in SDS-PAGE under reducing conditions.
-
Purity
> 90 % as determined by SDS-PAGE
-
Validations
Human ETHE1 / HSCO Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"