PER2 antibody

PER2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PER2 Rabbit Polyclonal antibody. Positive WB detected in L02 cells, HeLa cells, K-562 cells. Positive IP detected in HEK-293 cells. Observed molecular weight by Western-blot: 136kd

ELISA, WB, IP

Human; other species not tested.

FASPS antibody; hPER2 antibody; KIAA0347 antibody; PER2 antibody; period homolog 2 (Drosophila) antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_022817). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PER2, also named as KIAA0347, is a component of the circadian clock mechanism which is essential for generating circadian rhythms. PER2 is a negative element in the circadian transcriptional loop. PER2 influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. It negatively regulates CLocK|NPAS2-BMAL1|BMAL2-induced transactivation. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) which is characterized by very early sleep onset and offset. The antibody is specific to PER2. It can recognize isoform1 and isoform2 of PER2.

• Lee Y, Jang AR, Francey LJ, Sehgal A, Hogenesch JB. KPNB1 mediates PER/CRY nuclear translocation and circadian clock function. eLife. 4:. 2015.