PEN (rat) peptide
Not For Human Use, Lab Use Only.
Cat.#: 301592
Special Price 278.30 USD
Availability:
3 weeks
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Product Name
PEN (rat) peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
AVDQDLGPEVPPENVLGALLRV
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Sequence
H-Ala-Val-Asp-Gln-Asp-Leu-Gly-Pro-Glu-Val-Pro-Pro-Glu-Asn-Val-Leu-Gly-Ala-Leu-Leu-Arg-Val-OH
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Length (aa)
22
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Peptide Purity (HPLC)
96.9%
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Molecular Formula
C102H169N27O33
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Molecular Weight
2301.5
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CAS No.
569364-13-2
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Source
Synthetic
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Form
Powder
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Description
The PEN fragment is a neuropeptide derived from the precursor protein proSAAS through post-translational processing by prohormone convertases and carboxypeptidase E. It is one of the most abundant peptides in the mouse hypothalamus and is notably present in neuropeptide Y neurons of the arcuate nucleus. PEN is generated as a single, defined peptide sequence, unlike other proSAAS-derived peptides which exist in multiple length variants.
Scientific studies have identified GPR83, a G protein-coupled receptor, as the specific receptor for PEN. PEN binds to and activates GPR83 with high affinity, leading to downstream signaling events such as the activation of phospholipase C and modulation of intracellular calcium levels. This receptor-ligand interaction has been demonstrated in various neural tissues, including the hypothalamus and hippocampus, as well as in heterologous cell systems. Furthermore, GPR83 exhibits functional interactions with GPR171, the receptor for another proSAAS-derived peptide, bigLEN, suggesting potential crosstalk between these neuropeptide systems in specific brain regions.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43. doi: 10.1126/scisignal.aad0694. PMID: 27117253; PMCID: PMC5147544.
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"