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Product Name
Human KIAA0101/p15 (His Tag) recombinant protein
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Description
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
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Protein name
PCNA-associated factor
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Protein short names
NS5ATP9; PAF; P15/PAF; L5; P15PAF; OEATC-1; P15(PAF); HEPATITIS C VIRUS NS5A-TRANSACTIVATED PROTEIN 9; OVEREXPRESSED IN ANAPLASTIC THYROID CARCINOMA 1; OEATC; OEATC1; HCV NS5A-TRANSACTIVATED PROTEIN 9; PCNA-ASSOCIATED FACTOR
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Uniprot ID
Q15004
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Gene Name
KIAA0101; NS5ATP9; PAF; L5
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PAF isoform 1 (NP_055551.1) (Met 1-Glu 111) was expressed, with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PAF consisting of 126 amino acids and has a calculated molecular mass of 13.8 KDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human KIAA0101 / p15 / PAF Protein (His Tag) SDS-PAGE
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