Recombinant PANK3 protein (His tag)

• DataSheet
• COA (Batch NP456609)
• Material Safety Data Sheets (MSDS)

Recombinant human Pantothenate kinase 3 (hPanK3) fragment (residues 1-370) is a high-purity protein designed for structural and biochemical studies. This soluble and stable fragment retains the catalytic domain essential for the phosphorylation of pantothenate, enabling research into coenzyme A biosynthesis regulation.

Pantothenate kinase 3 (hPanK3), encoded by the PANK3 gene, catalyzes the phosphorylation of pantothenate to produce 4'-phosphopantothenate, which is the first and rate-determining step in coenzyme A (CoA) synthesis. CoA is a critical cofactor involved in numerous metabolic pathways, including fatty acid metabolism and the citric acid cycle. The full-length protein is localized in the cytoplasm, where it performs its essential role in cellular energy metabolism. This recombinant fragment (residues 1-370) encompasses the functional domain, providing a reliable tool for investigating enzymatic activity and mechanisms in CoA biosynthesis.

MSKIKHHHHH HGGSMKIKDA KKPSFPWFGM DIGGTLVKLS YFEPIDITAE EEQEEVESLK SIRKYLTSNV AYGSTGIRDV
HLELKDLTLF GRRGNLHFIR FPTQDLPTFI QMGRDKNFST LQTVLCATGG GAYKFEKDFR TIGNLHLHKL DELDCLVKGL
LYIDSVSFNG QAECYYFANA SEPERCQKMP FNLDDPYPLL VVNIGSGVSI LAVHSKDNYK RVTGTSLGGG TFLGLCSLLT
GCESFEEALE MASKGDSTQA DKLVRDIYGG DYERFGLPGW AVASSFGNMI YKEKRESVSK EDLARATLVT ITNNIGSVAR
MCAVNEKINR VVFVGNFLRV NTLSMKLLAY ALDYWSKGQL KALFLEHEGY FGAVGALLGL PNFS