• p28 peptide

p28 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319086

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Optional Service: TFA RemovalWhat's this?

Special Price 237.9 USD

Availability: 3 weeks
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Product Information

  • Product Name
    p28 peptide
  • Documents
  • Sequence
    H-LSTAADMQGVVTDGMASGLDKDYLKPDD-OH
  • Three letter code
    H-Leu-Ser-Thr-Ala-Ala-Asp-Met-Gln-Gly-Val-Val-Thr-Asp-Gly-Met-Ala-Ser-Gly-Leu-Asp-Lys-Asp-Tyr-Leu-Lys-Pro-Asp-Asp-OH
  • Length (aa)
    28
  • Peptide Purity (HPLC)
    95.59%
  • Molecular Formula
    C122H197N31O47S2
  • Molecular Weight
    2914.16
  • Source
    Synthetic
  • Additional Information
    p28 is an amphipathic, α-helical, cell penetrating peptide composed of amino acids Leu50-Asp77 of azurin, a redox protein secreted from the opportunistic pathogen pseudomonas aeruginosa. p28 is a post translational, multitarget anticancer agent that preferentially enters a wide variety of solid tumour cells. On entry, p28 binds to both wild-type and mutant p53 protein, inhibiting constitutional morphogenic protein 1 (cop1) mediated ubiquitination and proteasomal degradation of p53, increasing levels of p53 which induce cell cycle arrest at G2/M and causing apoptosis that results in tumour cell shrinkage and death.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Mehta et al (2011) A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis 14(3) 355 PMID: 21667138
    • Yamada et al (2013) p28, a first in class peptide inhibitor of cop1 binding to p53. Br J Cancer. 108(12) 2495 PMID: 23736031
    • Yaghoubi et al (2020) p28 Bacterial Peptide, as an Anticancer Agent. Front Oncol. 2020 10 1303 PMID: 32850408
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"