P10 peptide
Not For Human Use, Lab Use Only.
Cat.#: 318927
Special Price 160.4 USD
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Product Name
P10 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-LAREYKKIVEKLKRWLRQVLRTLR-OH
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Sequence
H-Leu-Ala-Arg-Glu-Tyr-Lys-Lys-Ile-Val-Glu-Lys-Leu-Lys-Arg-Trp-Leu-Arg-Gln-Val-Leu-Arg-Thr-Leu-Arg-OH
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Length (aa)
24
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Peptide Purity (HPLC)
95.73%
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Molecular Formula
C142H247N45O32
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Molecular Weight
3096.75
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Source
Synthetic
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Form
Powder
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Description
Shorter peptides derived from LL-37, such as P10 (LAREYKKIVEKLKRWLRQVLRTLR), have also shown antimicrobial activity. P10 was more effective at killing the methicillin-resistant S. aureus (MRSA) strain LUH14616 than LL-37, and it could eradicate MRSA strains LUH14616 and LUH15051 from thermally wounded human skin equivalents in vitro without showing toxicity towards the fibroblasts and keratinocytes within the tissue models.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Haisma EM et al (2014) LL-37-derived peptides eradicate multidrug-resistant Staphylococcus
- aureus from thermally wounded human skin equivalents. Antimicrob Agents Chemother
- 58:4411. https://doi.org/10.1128/AAC.02554-14
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"