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Product Name
Cynomolgus OLR1/LOX1 (His Tag) recombinant protein
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Description
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions.Â
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Protein name
Oxidized low-density lipoprotein receptor 1
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Protein short names
SCARE1; LOXIN; LOX-1; SLOX1; SR-EI; CLEC8A; LOX1
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Uniprot ID
G7PJT2
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Gene Name
EGM_02972
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus OLR1 (G7PJT2) (Ser61-Gln273) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant heterodimer of cynomolgus OLR1 comprises 233 amino acids and has a calculated molecular mass of 26.9 KDa. The apparent molecular mass of the protein is approximately 37 KDa respectively in SDS-PAGE.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Cynomolgus OLR1 / LOX1 Protein (His Tag) SDS-PAGE
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