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Product Name
Human CD200 (His & Fc Tag) recombinant protein
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Description
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
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Protein name
OX-2 membrane glycoprotein
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Protein short names
CD200; OX2; OX-2; MOX2; MOX1; MRC
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Uniprot ID
P41217
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Gene Name
CD200; MOX1; MOX2; My033
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CD200 (NP_005935.4) extracellular domain (Met 1-Gly 232) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD200/Fc is a disulfide-linked homodimer. The reduced monomer consists of 450 amino acids and has a predicted molecular mass of 50.5 kDa. As a result of glycosylation, the apparent molecular mass of rh CD200/Fc monomer is approximately 65-70 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human CD200R1 at 1 μg/ml (100 μl/well) can bind human CD200 Fc Chimera with a linear range of 0.12-16 ng/ml.
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Validations
Human CD200 / OX-2 Protein (His & Fc Tag) SDS-PAGE
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